I would consider a tow company. I know Marc at Wefings in Apalachicola is a good guy to talk boats, and does lots of towing and knows other towing companies.
Take the boat and trailer and have it weighed to know. Without knowing the truck specs I would be very cautious.
Determine tongue weight, too. I would carry extra trailer tires. Stop every a couple hours and use digital thermometer and check tires and hubs temps. Check tire pressure when cold. Add a LED tow light across transom to help prevent being rear ended. Be well rested and make truck comfortable so the other driver can sleep. First person is tired then switch driver, If booth tired, pull off and rest. Drink plenty of fluids but watch the caffeine and eat regularly and lightly. Avoid sugar highs. Stay in premium hotels and thank me later about not being attacked by bedbugs and often, hotels has security but take in as most stuff into room as possible. Keep your keys by bed. If you hear anything near truck press the alarm button.
Drive 60 mph if possible and slow down when in traffic. Easy to type and hard to do but get home safe is the goal.
Plan your drive time
We drive in SW Florida from Indy frequently and leave in afternoon to early evening to avoid heavy traffic in Louisville, Nashville, Chattanooga, Atlanta and Ocala. We take turns driving and drive safely. We slow down or pull off if near aggressive drivers esp the drunks. The only major traffic is Tampa in the morning but it often just slows down and rarely all traffic is stopped and stand on I75 and not into the city. It is 1100 miles one way with 16 -18 hours depending on traffic and road construction
I would worry about truck tires, engine coolant, oil and trans overheating. I would turn off AC, too
We broke down on 75 in Macon in a bad part of town. It took 2 hours for a tow and I called a cab for my family to the nice part of town to a good hotel.
In the am I took a cab and bought a idler pulley bearing and serpentine belt and installed in parking lot
If carrying firearms, know each state laws. mostly do not like you carrying loaded weapons and want them in a locked box.
No drinking or booze in the truck too.