DMD,
Attached is a performance bulletin from Yamaha. They used your set up. Great numbers for your boat throughout but I have some doubts about the full tank of fuel and a top speed of 45 mph. Their info also shows a t-top so I'm wondering if they have some information confused with another test. However, I'm sure these numbers are in the ball park. 4,000 rpms seems to be the sweet spot and will get you close to that 2 mpg.
Just realize that these tests are always in ideal conditions and the boats tested are new and don't have the added weight of a boat that's regularly used or has a few years behind it, nor does it have anything outside to add to wind resistance. Not to mention holding tanks, through hull fittings and strainers, additional transducers, and other items that cause water resistance.
I have a single F250 and in the bay on a calm day, I can hit 2 mpg with approximatley 3/4 tank of fuel (I hold 154 gallons) and two big adults. The older Deep V 2530s were sometimes rigged with a single engine. Part of the reason being a fuel tank being 20 gallons smaller than the new ones. But I'm still loaded with options including a strainer under the hull and two transom mounted transducers. All fuel and speed robbing accessories. My top speed with a full tank of gas, fishing gear, a couple of people, and a calm bay is about 35 mph. Throw in a chop, some two to three foot swells, and some boat traffic and I slow down significantly.
I keep my boat in Point Pleasant, NJ and usually fish in the ocean out of Manasquan inlet. With normal conditions, if I drive faster than 25 to 30 mph, I take a beating because of the South West winds. This type of operation normally puts me at about 1.5 mpg.
Hope this helps.
http://www.yamaha-motor.com/assets/prod ... 150txr.pdf